The First Shot plunges viewers into Northeast in 1997, a pivotal time just before the Narcotics Control Bureau was established. When a sudden and perplexing drug crisis erupts, an urgent response is needed. A makeshift elite team, each member possessing unique strengths but united by their inexperience with this new, mysterious substance, is swiftly assembled.
Their mission leads them directly into a dangerous confrontation with a ruthless drug trafficking syndicate. As they endeavor to unravel the syndicate's bizarre and intricate schemes, the team faces profound moral dilemmas, forcing them to choose between love and the law, and confronting challenging tests of justice and humanity. Standing united, they navigate treacherous obstacles and overcome immense challenges, ultimately forging a heroic legend of unwavering dedication to fighting evil and upholding justice.